| All Time Matchup | DET - 6 || IND - 1 || 0 ties Last Game: Week 21, 1988 - Indianapolis Colts - 34 @ Detroit Lions - 27 | | Record | 7-9-0 (2-5-0 Away) |
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| Coach | Nick Miller |
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| Off Scheme | WestCoastHybrid |
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| Def Scheme | D43Hybrid |
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| Offense | Overall - 5949(11) : Pass - 4297(8) : Rush - 1652(18) |
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| Defense | Overall - 5839(12) : Pass - 3946(12) : Rush - 1893(7) |
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| Leading Passer | John Elway - 3842 |
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| Leading Rusher | Marcus Allen - 870 |
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| Leading Receiver | Mike Williams - 1237 |
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| Leading Tackler | David Harris - 133 |
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| Turnovers | 28 Take Aways / 22 Turn Overs (+6) |
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| Penalties | 104 For 887 Yards |
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| | Record | 10-6-0 (6-2-0 Home) |
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| Coach | Tony Dungy |
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| Off Scheme | ProStyle |
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| Def Scheme | D43Hybrid |
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| Offense | Overall - 5547(13) : Pass - 3270(12) : Rush - 2277(9) |
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| Defense | Overall - 5493(5) : Pass - 3748(10) : Rush - 1745(4) |
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| Leading Passer | Jim Kelly - 2144 |
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| Leading Rusher | Curt Warner - 1154 |
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| Leading Receiver | Eddie Brown - 1096 |
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| Leading Tackler | Todd Lyght - 103 |
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| Turnovers | 19 Take Aways / 18 Turn Overs (+1) |
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| Penalties | 99 For 817 Yards |
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| Last Game Starters |
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Detroit Lions Offense| Quarterback | John Elway |
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| Running Backs | Marcus Allen - James Jones FB II |
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| Receivers | Greg Jennings - Mike Williams |
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| Tight End | Isaiah Likely |
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| Offensive Line | Bruce Matthews - Jim Sweeney - Kevin Glover - Flozell Adams - Jimbo Covert |
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Detroit Lions Defense
| Defensive Line | Clyde Simmons - Keith Millard - Joe Nash - Tim Harris |
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| Linebackers | Duane Bickett - David Harris - Randall Godfrey |
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| Cornerbacks | R.W. McQuarters - Cam Taylor-Britt |
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| Safeties | Kyle Hamilton - Lawyer Milloy |
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| Kicker / Punter | Matt Stover - Jordan Stout |
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| Indianapolis Colts Offense| Quarterback | Jim Kelly |
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| Running Backs | Curt Warner - Tom Rathman |
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| Receivers | Eddie Brown - Hines Ward |
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| Tight End | Rickey Dudley |
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| Offensive Line | Jonathan Ogden - Eric Moten - Luke Fortner - Brandon Burlsworth - Evan Neal |
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Indianapolis Colts Defense
| Defensive Line | Chris Doleman - Bronko Nagurski - La'Roi Glover - Bruce Smith |
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| Linebackers | Jack Sanborn - Matt Millen - Brian Asamoah II |
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| Cornerbacks | Dick LeBeau - Roger McCreary |
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| Safeties | Emlen Tunnell - Todd Lyght |
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| Kicker / Punter | Stephen Gostkowski - Rohn Stark |
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| Injuries |
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Detroit Lions Injuries
| Duane Bickett (LB) | Bulging Disc (Back) (Out (2-4 weeks)) |
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| Randall Godfrey (LB) | Pulled Hamstring (Questionable) |
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| David Harris (LB) | Sprained Ankle (Questionable) |
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| Indianapolis Colts Injuries
| Bronko Nagurski (DT) | Scratched Cornea (Probable) |
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| Paul Warfield (WR) | Blurred Vision (Probable) |
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| Roger McCreary (CB) | Hyper Extended Knee (Questionable) |
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| Tom Rathman (FB) | Sprained Wrist (Probable) |
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