| All Time Matchup | BUF - 0 || SF - 5 || 0 ties
Last Game: Week 15, 1988 - San Francisco 49ers - 35 @ Buffalo Bills - 17 | | Record | 0-0-0 (0-0-0 Away) |
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| Coach | Marv Levy |
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| Off Scheme | SpreadHybrid |
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| Def Scheme | D43 |
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| Offense | Overall - 0(16) : Pass - 0(16) : Rush - 0(16) |
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| Defense | Overall - 0(16) : Pass - 0(16) : Rush - 0(16) |
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| Leading Passer | - |
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| Leading Rusher | - |
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| Leading Receiver | - |
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| Leading Tackler | - |
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| Turnovers | 0 Take Aways / 0 Turn Overs (0) |
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| Penalties | 0 For 0 Yards |
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| | Record | 0-0-0 (0-0-0 Home) |
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| Coach | Grace Savage |
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| Off Scheme | SpreadHybrid |
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| Def Scheme | D34 |
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| Offense | Overall - 0(7) : Pass - 0(7) : Rush - 0(7) |
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| Defense | Overall - 0(7) : Pass - 0(7) : Rush - 0(7) |
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| Leading Passer | - |
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| Leading Rusher | - |
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| Leading Receiver | - |
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| Leading Tackler | - |
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| Turnovers | 0 Take Aways / 0 Turn Overs (0) |
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| Penalties | 0 For 0 Yards |
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| Last Game Starters |
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Buffalo Bills Offense| Quarterback | Mike Ngo |
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| Running Backs | Greg Bell - Tuffy Leemans |
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| Receivers | Andre Reed - Steve Tasker |
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| Tight End | Pete Metzelaars |
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| Offensive Line | Eric Young - Jahri Evans - Nick Mangold - Cam Jurgens - Nicholas Petit-Frere |
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Buffalo Bills Defense
| Defensive Line | Reggie White - Russell Maryland - Darryl Grant - Simeon Rice |
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| Linebackers | Bobby Boucher - Mike Singletary - Lawrence Taylor |
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| Cornerbacks | Marcus Jones CB - Mike Mickens |
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| Safeties | Eugene Robinson - James Ihedigbo |
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| Kicker / Punter | Nick Folk - Jake Camarda |
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San Francisco 49ers Offense| Quarterback | Bernie Kosar |
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| Running Backs | Joe Morris - Mike Rozier |
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| Receivers | Brandon Marshall - Jerry Rice |
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| Tight End | Steve Jordan |
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| Offensive Line | Willie Anderson - Mike Munchak - Bart Oates - Dylan Parham - James Williams |
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San Francisco 49ers Defense
| Defensive Line | Charles Mann - Remi Ayodele - Leonard Marshall |
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| Linebackers | Nik Bonitto - Mike Merriweather - Johnny Rembert - Freddie Joe Nunn |
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| Cornerbacks | Frank Minnifield - Ray Horton |
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| Safeties | Reed Blankenship - Dennis Smith |
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| Kicker / Punter | Scott Blanton - Jon Ryan |
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| Injuries |
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Buffalo Bills Injuries
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San Francisco 49ers Injuries
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