Round 1
| Round | Pick | Team | Selection |
|---|
| 1 | 1 | 19 | Calvin Johnson |
| 1 | 2 | 18 | Darrelle Revis |
| 1 | 3 | 18 (from MIN) | Adrian Peterson |
| 1 | 4 | 16 | Art Donovan |
| 1 | 5 | 11 | Patrick Willis |
| 1 | 6 | 20 | Joe Thomas |
| 1 | 7 | 6 | Lemar Parrish |
| 1 | 8 | 16 (from GB) | LaMarr Woodley |
| 1 | 9 | 1 | Jon Beason |
| 1 | 10 | 8 | Marshal Yanda |
| 1 | 11 | 10 (from CHC) | Ken Stabler |
| 1 | 12 | 4 | Marshawn Lynch |
| 1 | 13 | 12 (from IND) | David Harris |
| 1 | 14 | 5 (from LON) | Mike Mickens |
| 1 | 15 | 5 | Eric Young |
| 1 | 16 | 15 | Ted Ginn Jr. |
| 1 | 17 | 5 (from ATL) | Sidney Rice |
| 1 | 18 | 10 (from CIN) | Ryan Grant |
| 1 | 19 | 11 (from DET) | Leon Hall |
| 1 | 20 | 2 | Josh Wilson |
Round 2
| Round | Pick | Team | Selection |
|---|
| 2 | 1 | 9 (from CLE) | Chinedum Ndukwe |
| 2 | 2 | 13 (from BAL) | George Trafton |
| 2 | 3 | 13 | Dwayne Bowe |
| 2 | 4 | 16 | James Jones WR |
| 2 | 5 | 11 | Kyle Cook |
| 2 | 6 | 20 | Keyunta Dawson |
| 2 | 7 | 6 | Greg Olsen |
| 2 | 8 | 9 (from GB) | Gaines Adams |
| 2 | 9 | 1 | Brent Celek |
| 2 | 10 | 8 | LaRon Landry |
| 2 | 11 | 9 (from CHC) | Lorenzo Booker |
| 2 | 12 | 4 | Jason Murphy |
| 2 | 13 | 10 | Levi Brown |
| 2 | 14 | 9 | Chris Gocong |
| 2 | 15 | 5 | Mike Sims-Walker |
| 2 | 16 | 15 | Eric Weddle |
| 2 | 17 | 19 (from ATL) | Stephon Heyer |
| 2 | 18 | 7 | Justin Blalock |
| 2 | 19 | 12 | Robert Meachem |
| 2 | 20 | 2 | Anthony Spencer |
Round 3
| Round | Pick | Team | Selection |
|---|
| 3 | 1 | 19 | Matt Blair II |
| 3 | 2 | 13 (from BAL) | Brady Quinn |
| 3 | 3 | 13 | Hiram Eugene |
| 3 | 4 | 16 | Matt Prater |
| 3 | 5 | 11 | Wayne Milner |
| 3 | 6 | 20 | Brett Goode |
| 3 | 7 | 6 | Jeromey Clary |
| 3 | 8 | 3 | Mason Crosby |
| 3 | 9 | 1 | Reggie Nelson |
| 3 | 10 | 8 | Eric Crouch |
| 3 | 11 | 9 (from CHC) | Zach Miller |
| 3 | 12 | 4 | Rico Dynamite |
| 3 | 13 | 10 | Charles Johnson |
| 3 | 14 | 15 (from LON) | Jamaal Anderson |
| 3 | 15 | 15 (from BUF) | William Gay |
| 3 | 16 | 15 | Uche Nwaneri |
| 3 | 17 | 19 (from ATL) | Stewart Bradley |
| 3 | 18 | 7 | Michael Otto |
| 3 | 19 | 12 | Kerry Reed |
| 3 | 20 | 2 | Ahmad Bradshaw |
Round 4
| Round | Pick | Team | Selection |
|---|
| 4 | 1 | 19 | Ray McDonald |
| 4 | 2 | 18 | Aaron Rouse |
| 4 | 3 | 13 | Tank Tyler |
| 4 | 4 | 16 | Gerald Alexander |
| 4 | 5 | 11 | Melvin Bullitt |
| 4 | 6 | 20 | Brent Grimes |
| 4 | 7 | 6 | Clint Session |
| 4 | 8 | 3 | Stylez G White |
| 4 | 9 | 1 | Allen Barbre |
| 4 | 10 | 8 | Joe Staley |
| 4 | 11 | 12 (from CHC) | Steve Van Buren |
| 4 | 12 | 4 | Ben Grubbs |
| 4 | 13 | 10 | Josh Gattis |
| 4 | 14 | 12 (from LON) | Jim Zorn II |
| 4 | 15 | 5 | Nick Folk |
| 4 | 16 | 15 | Remi Ayodele |
| 4 | 17 | 7 (from ATL) | Eric Wright |
| 4 | 18 | 7 | Samson Satele |
| 4 | 19 | 9 (from DET) | Paul Soliai |
| 4 | 20 | 2 | Courtney Taylor |
Round 5
| Round | Pick | Team | Selection |
|---|
| 5 | 1 | 19 | Antonio Johnson |
| 5 | 2 | 18 | Jacoby Jones |
| 5 | 3 | 13 | Akeem Jordan |
| 5 | 4 | 16 | Chris Houston |
| 5 | 5 | 11 | Amobi Okoye |
| 5 | 6 | 20 | Laurent Robinson |
| 5 | 7 | 16 (from NYG) | Paul Jefferson |
| 5 | 8 | 11 (from GB) | Pierre Thomas |
| 5 | 9 | 1 | Brandon McDonald |
| 5 | 10 | 8 | Ryan Kalil |
| 5 | 11 | 17 | Devin Aromashodu |
| 5 | 12 | 4 | Jeff Charleston |
| 5 | 13 | 10 | Tyron Brackenridge |
| 5 | 14 | 9 | Tyler Thigpen |
| 5 | 15 | 7 (from BUF) | C.J. Wilson |
| 5 | 16 | 15 | Dave Tollefson |
| 5 | 17 | 14 | Ryan Harris |
| 5 | 18 | 7 | Garrett Mills |
| 5 | 19 | 12 | Geoffrey Pope |
| 5 | 20 | 3 (from MIA) | Michael Griffin |
Round 6
| Round | Pick | Team | Selection |
|---|
| 6 | 1 | 19 | Manuel Ramirez |
| 6 | 2 | 18 | Mike Hass |
| 6 | 3 | 13 | Craig Dahl |
| 6 | 4 | 16 | Steve Breaston |
| 6 | 5 | 11 | Lyle Sendlein |
| 6 | 6 | 20 | Chris Denman |
| 6 | 7 | 6 | Dan Santucci |
| 6 | 8 | 10 (from GB) | Kevin Hobbs |
| 6 | 9 | 1 | Tanard Jackson |
| 6 | 10 | 8 | David Jones |
| 6 | 11 | 17 | Ron Jaworski II |
| 6 | 12 | 4 | Edward Johnson |
| 6 | 13 | 10 | Turk McBride |
| 6 | 14 | 19 (from LON) | Troy Smith |
| 6 | 15 | 5 | Antonio Pittman |
| 6 | 16 | 15 | Lawrence Timmons |
| 6 | 17 | 14 | Drew Stanton |
| 6 | 18 | 7 | DeShawn Wynn |
| 6 | 19 | 12 | Quincy Black |
| 6 | 20 | 2 | Jay Richardson |
Round 7
| Round | Pick | Team | Selection |
|---|
| 7 | 1 | 19 | Arron Sears |
| 7 | 2 | 18 | Jordan Palmer |
| 7 | 3 | 13 | Richmond McGee |
| 7 | 4 | 16 | Kevin Kolb |
| 7 | 5 | 11 | Craphonso Thorpe |
| 7 | 6 | 20 | Kyle Eckel |
| 7 | 7 | 3 (from NYG) | JaMarcus Russell |
| 7 | 8 | 5 (from GB) | Derek Landri |
| 7 | 9 | 1 | Rodrique Wright |
| 7 | 10 | 9 (from SEA) | Chris Davis |
| 7 | 11 | 17 | Jermon Bushrod |
| 7 | 12 | 4 | Dwayne Wright |
| 7 | 13 | 12 (from IND) | David Kirtman |
| 7 | 14 | 9 | Kelvin Smith |
| 7 | 15 | 5 | Desmond Bishop |
| 7 | 16 | 15 | Tarell Brown |
| 7 | 17 | 14 | C.J. Wallace |
| 7 | 18 | 7 | Selvin Young |
| 7 | 19 | 12 | John Dekker |
| 7 | 20 | 2 | Kevin Boss |
