| Round | Pick | Team | Selection |
|---|---|---|---|
| 1 | 1 | Cleveland Browns | Calvin Johnson |
| 1 | 2 | Baltimore Ravens | Darrelle Revis |
| 1 | 3 | Baltimore Ravens (from MIN) | Adrian Peterson |
| 1 | 4 | Tampa Bay Buccanneers | Art Donovan |
| 1 | 5 | Chicago Bears | Patrick Willis |
| 1 | 6 | New York Jets | Joe Thomas |
| 1 | 7 | New York Giants | Lemar Parrish |
| 1 | 8 | Tampa Bay Buccanneers (from GB) | LaMarr Woodley |
| 1 | 9 | Kansas City Chiefs | Jon Beason |
| 1 | 10 | Seattle Seahawks | Marshal Yanda |
| 1 | 11 | Indianapolis Colts (from CHC) | Ken Stabler |
| 1 | 12 | Oakland Raiders | Marshawn Lynch |
| 1 | 13 | Detroit Lions (from IND) | David Harris |
| 1 | 14 | Buffalo Bills (from LON) | Mike Mickens |
| 1 | 15 | Buffalo Bills | Eric Young |
| 1 | 16 | San Francisco 49ers | Ted Ginn Jr. |
| 1 | 17 | Buffalo Bills (from ATL) | Sidney Rice |
| 1 | 18 | Indianapolis Colts (from CIN) | Ryan Grant |
| 1 | 19 | Chicago Bears (from DET) | Leon Hall |
| 1 | 20 | Miami Dolphins | Josh Wilson |
| Round | Pick | Team | Selection |
|---|---|---|---|
| 2 | 1 | London Monarchs (from CLE) | Chinedum Ndukwe |
| 2 | 2 | Minnesota Vikings (from BAL) | George Trafton |
| 2 | 3 | Minnesota Vikings | Dwayne Bowe |
| 2 | 4 | Tampa Bay Buccanneers | James Jones WR |
| 2 | 5 | Chicago Bears | Kyle Cook |
| 2 | 6 | New York Jets | Keyunta Dawson |
| 2 | 7 | New York Giants | Greg Olsen |
| 2 | 8 | London Monarchs (from GB) | Gaines Adams |
| 2 | 9 | Kansas City Chiefs | Brent Celek |
| 2 | 10 | Seattle Seahawks | LaRon Landry |
| 2 | 11 | London Monarchs (from CHC) | Lorenzo Booker |
| 2 | 12 | Oakland Raiders | Jason Murphy |
| 2 | 13 | Indianapolis Colts | Levi Brown |
| 2 | 14 | London Monarchs | Chris Gocong |
| 2 | 15 | Buffalo Bills | Mike Sims-Walker |
| 2 | 16 | San Francisco 49ers | Eric Weddle |
| 2 | 17 | Cleveland Browns (from ATL) | Stephon Heyer |
| 2 | 18 | Cincinnati Bengals | Justin Blalock |
| 2 | 19 | Detroit Lions | Robert Meachem |
| 2 | 20 | Miami Dolphins | Anthony Spencer |
| Round | Pick | Team | Selection |
|---|---|---|---|
| 3 | 1 | Cleveland Browns | Matt Blair II |
| 3 | 2 | Minnesota Vikings (from BAL) | Brady Quinn |
| 3 | 3 | Minnesota Vikings | Hiram Eugene |
| 3 | 4 | Tampa Bay Buccanneers | Matt Prater |
| 3 | 5 | Chicago Bears | Wayne Milner |
| 3 | 6 | New York Jets | Brett Goode |
| 3 | 7 | New York Giants | Jeromey Clary |
| 3 | 8 | Green Bay Packers | Mason Crosby |
| 3 | 9 | Kansas City Chiefs | Reggie Nelson |
| 3 | 10 | Seattle Seahawks | Eric Crouch |
| 3 | 11 | London Monarchs (from CHC) | Zach Miller |
| 3 | 12 | Oakland Raiders | Rico Dynamite |
| 3 | 13 | Indianapolis Colts | Charles Johnson |
| 3 | 14 | San Francisco 49ers (from LON) | Jamaal Anderson |
| 3 | 15 | San Francisco 49ers (from BUF) | William Gay |
| 3 | 16 | San Francisco 49ers | Uche Nwaneri |
| 3 | 17 | Cleveland Browns (from ATL) | Stewart Bradley |
| 3 | 18 | Cincinnati Bengals | Michael Otto |
| 3 | 19 | Detroit Lions | Kerry Reed |
| 3 | 20 | Miami Dolphins | Ahmad Bradshaw |
| Round | Pick | Team | Selection |
|---|---|---|---|
| 4 | 1 | Cleveland Browns | Ray McDonald |
| 4 | 2 | Baltimore Ravens | Aaron Rouse |
| 4 | 3 | Minnesota Vikings | Tank Tyler |
| 4 | 4 | Tampa Bay Buccanneers | Gerald Alexander |
| 4 | 5 | Chicago Bears | Melvin Bullitt |
| 4 | 6 | New York Jets | Brent Grimes |
| 4 | 7 | New York Giants | Clint Session |
| 4 | 8 | Green Bay Packers | Stylez G White |
| 4 | 9 | Kansas City Chiefs | Allen Barbre |
| 4 | 10 | Seattle Seahawks | Joe Staley |
| 4 | 11 | Detroit Lions (from CHC) | Steve Van Buren |
| 4 | 12 | Oakland Raiders | Ben Grubbs |
| 4 | 13 | Indianapolis Colts | Josh Gattis |
| 4 | 14 | Detroit Lions (from LON) | Jim Zorn II |
| 4 | 15 | Buffalo Bills | Nick Folk |
| 4 | 16 | San Francisco 49ers | Remi Ayodele |
| 4 | 17 | Cincinnati Bengals (from ATL) | Eric Wright |
| 4 | 18 | Cincinnati Bengals | Samson Satele |
| 4 | 19 | London Monarchs (from DET) | Paul Soliai |
| 4 | 20 | Miami Dolphins | Courtney Taylor |
| Round | Pick | Team | Selection |
|---|---|---|---|
| 5 | 1 | Cleveland Browns | Antonio Johnson |
| 5 | 2 | Baltimore Ravens | Jacoby Jones |
| 5 | 3 | Minnesota Vikings | Akeem Jordan |
| 5 | 4 | Tampa Bay Buccanneers | Chris Houston |
| 5 | 5 | Chicago Bears | Amobi Okoye |
| 5 | 6 | New York Jets | Laurent Robinson |
| 5 | 7 | Tampa Bay Buccanneers (from NYG) | Paul Jefferson |
| 5 | 8 | Chicago Bears (from GB) | Pierre Thomas |
| 5 | 9 | Kansas City Chiefs | Brandon McDonald |
| 5 | 10 | Seattle Seahawks | Ryan Kalil |
| 5 | 11 | Chicago Cardinals | Devin Aromashodu |
| 5 | 12 | Oakland Raiders | Jeff Charleston |
| 5 | 13 | Indianapolis Colts | Tyron Brackenridge |
| 5 | 14 | London Monarchs | Tyler Thigpen |
| 5 | 15 | Cincinnati Bengals (from BUF) | C.J. Wilson |
| 5 | 16 | San Francisco 49ers | Dave Tollefson |
| 5 | 17 | Atlanta Falcons | Ryan Harris |
| 5 | 18 | Cincinnati Bengals | Garrett Mills |
| 5 | 19 | Detroit Lions | Geoffrey Pope |
| 5 | 20 | Green Bay Packers (from MIA) | Michael Griffin |
| Round | Pick | Team | Selection |
|---|---|---|---|
| 6 | 1 | Cleveland Browns | Manuel Ramirez |
| 6 | 2 | Baltimore Ravens | Mike Hass |
| 6 | 3 | Minnesota Vikings | Craig Dahl |
| 6 | 4 | Tampa Bay Buccanneers | Steve Breaston |
| 6 | 5 | Chicago Bears | Lyle Sendlein |
| 6 | 6 | New York Jets | Chris Denman |
| 6 | 7 | New York Giants | Dan Santucci |
| 6 | 8 | Indianapolis Colts (from GB) | Kevin Hobbs |
| 6 | 9 | Kansas City Chiefs | Tanard Jackson |
| 6 | 10 | Seattle Seahawks | David Jones |
| 6 | 11 | Chicago Cardinals | Ron Jaworski II |
| 6 | 12 | Oakland Raiders | Edward Johnson |
| 6 | 13 | Indianapolis Colts | Turk McBride |
| 6 | 14 | Cleveland Browns (from LON) | Troy Smith |
| 6 | 15 | Buffalo Bills | Antonio Pittman |
| 6 | 16 | San Francisco 49ers | Lawrence Timmons |
| 6 | 17 | Atlanta Falcons | Drew Stanton |
| 6 | 18 | Cincinnati Bengals | DeShawn Wynn |
| 6 | 19 | Detroit Lions | Quincy Black |
| 6 | 20 | Miami Dolphins | Jay Richardson |
| Round | Pick | Team | Selection |
|---|---|---|---|
| 7 | 1 | Cleveland Browns | Arron Sears |
| 7 | 2 | Baltimore Ravens | Jordan Palmer |
| 7 | 3 | Minnesota Vikings | Richmond McGee |
| 7 | 4 | Tampa Bay Buccanneers | Kevin Kolb |
| 7 | 5 | Chicago Bears | Craphonso Thorpe |
| 7 | 6 | New York Jets | Kyle Eckel |
| 7 | 7 | Green Bay Packers (from NYG) | JaMarcus Russell |
| 7 | 8 | Buffalo Bills (from GB) | Derek Landri |
| 7 | 9 | Kansas City Chiefs | Rodrique Wright |
| 7 | 10 | London Monarchs (from SEA) | Chris Davis |
| 7 | 11 | Chicago Cardinals | Jermon Bushrod |
| 7 | 12 | Oakland Raiders | Dwayne Wright |
| 7 | 13 | Detroit Lions (from IND) | David Kirtman |
| 7 | 14 | London Monarchs | Kelvin Smith |
| 7 | 15 | Buffalo Bills | Desmond Bishop |
| 7 | 16 | San Francisco 49ers | Tarell Brown |
| 7 | 17 | Atlanta Falcons | C.J. Wallace |
| 7 | 18 | Cincinnati Bengals | Selvin Young |
| 7 | 19 | Detroit Lions | John Dekker |
| 7 | 20 | Miami Dolphins | Kevin Boss |