| Round | Pick | Team | Selection |
|---|---|---|---|
| 1 | 1 | Indianapolis Colts | Paul Warfield |
| 1 | 2 | Green Bay Packers | Emlen Tunnell |
| 1 | 3 | Chicago Bears | Kyle Williams |
| 1 | 4 | Buffalo Bills | Jahri Evans |
| 1 | 5 | Seattle Seahawks (CLE) | Maurice Jones-Drew |
| 1 | 6 | New York Jets | Donald Penn |
| 1 | 7 | New York Giants | Jay Cutler |
| 1 | 8 | Washington [Redacted]s (CHC) | Bobby Boucher |
| 1 | 9 | Minnesota Vikings | Devin Hester |
| 1 | 10 | Kansas City Chiefs | Vince Young |
| 1 | 11 | Miami Dolphins | Haloti Ngata |
| 1 | 12 | Baltimore Ravens | D'Brickashaw Ferguson |
| 1 | 13 | London Monarchs | Greg Jennings |
| 1 | 14 | Providence Steam Rollers (SEA) | Mario Williams |
| 1 | 15 | Green Bay Packers (from TB) | Tramon Williams |
| 1 | 16 | San Francisco 49ers | Brandon Marshall |
| 1 | 17 | Buffalo Bills (from OAK) | Nick Mangold |
| 1 | 18 | Chicago Bears (from DET) | Tommy Nobis |
| 1 | 19 | Buffalo Bills (from CIN) | Marcus McNeill |
| 1 | 20 | London Monarchs (from ATL) | Dave Butz II |
| Round | Pick | Team | Selection |
|---|---|---|---|
| 2 | 1 | New York Giants (from IND) | Reggie Bush |
| 2 | 2 | Green Bay Packers | Kamerion Wimbley |
| 2 | 3 | Chicago Bears | Andrew Whitworth |
| 2 | 4 | Cincinnati Bengals (from BUF) | Joseph Addai |
| 2 | 5 | Seattle Seahawks (CLE) | A.J. Hawk |
| 2 | 6 | New York Jets | Marques Colston |
| 2 | 7 | New York Giants | DeMeco Ryans |
| 2 | 8 | Washington [Redacted]s (CHC) | James Brooks II |
| 2 | 9 | Minnesota Vikings | Chris Kuper |
| 2 | 10 | Kansas City Chiefs | Miles Austin |
| 2 | 11 | Miami Dolphins | Marcedes Lewis |
| 2 | 12 | Baltimore Ravens | John Kuhn |
| 2 | 13 | London Monarchs | Frostee Rucker |
| 2 | 14 | Providence Steam Rollers (SEA) | Elvis Dumervil |
| 2 | 15 | Green Bay Packers (from TB) | Chris Chester |
| 2 | 16 | San Francisco 49ers | Cortland Finnegan |
| 2 | 17 | Oakland Raiders | Mike Brisiel |
| 2 | 18 | Detroit Lions | Mike Williams |
| 2 | 19 | Buffalo Bills (from CIN) | Tuffy Leemans |
| 2 | 20 | Buffalo Bills (from ATL) | James Ihedigbo |
| Round | Pick | Team | Selection |
|---|---|---|---|
| 3 | 1 | Indianapolis Colts | Ernie Sims |
| 3 | 2 | Green Bay Packers | Randy Gradishar |
| 3 | 3 | Chicago Bears | Jason Campbell |
| 3 | 4 | Buffalo Bills | Owen Daniels |
| 3 | 5 | Seattle Seahawks (CLE) | Antonio Cromartie |
| 3 | 6 | New York Jets | Donte Whitner |
| 3 | 7 | New York Giants | Johnny Jolly |
| 3 | 8 | New York Giants (from CHC) | Eric Winston |
| 3 | 9 | Minnesota Vikings | Kirk Gibson |
| 3 | 10 | Kansas City Chiefs | Daryn Colledge |
| 3 | 11 | Miami Dolphins | Melvin Oliver |
| 3 | 12 | Baltimore Ravens | Antoine Bethea |
| 3 | 13 | London Monarchs | Will Blackmon |
| 3 | 14 | Providence Steam Rollers (SEA) | Tamba Hali |
| 3 | 15 | Tampa Bay Buccanneers | Deuce Lutui |
| 3 | 16 | San Francisco 49ers | Dawan Landry |
| 3 | 17 | Oakland Raiders | Jeremy Trueblood |
| 3 | 18 | Chicago Bears (from DET) | Chad Greenway |
| 3 | 19 | Cincinnati Bengals | Barry Cofield |
| 3 | 20 | Green Bay Packers (from ATL) | DeAngelo Williams |
| Round | Pick | Team | Selection |
|---|---|---|---|
| 4 | 1 | Indianapolis Colts | Vernon Davis |
| 4 | 2 | London Monarchs (from GB) | Winston Justice |
| 4 | 3 | Chicago Bears | Santonio Holmes |
| 4 | 4 | Green Bay Packers (from BUF) | Charlie Johnson |
| 4 | 5 | Seattle Seahawks (CLE) | Adam Stenavich |
| 4 | 6 | New York Jets | Matt Leinart |
| 4 | 7 | Washington [Redacted]s (CHC) (from NYG) | Roman Harper |
| 4 | 8 | Washington [Redacted]s (CHC) | Greg Camarillo |
| 4 | 9 | Minnesota Vikings | Domata Peko |
| 4 | 10 | Kansas City Chiefs | Ray Edwards |
| 4 | 11 | Green Bay Packers (from MIA) | Willie Colon |
| 4 | 12 | Baltimore Ravens | Laurence Maroney |
| 4 | 13 | London Monarchs | Danieal Manning |
| 4 | 14 | Providence Steam Rollers (SEA) | Colin Cole |
| 4 | 15 | Tampa Bay Buccanneers | Anthony Montgomery |
| 4 | 16 | San Francisco 49ers | Mathias Kiwanuka |
| 4 | 17 | Oakland Raiders | Patrick Cobbs |
| 4 | 18 | Indianapolis Colts (from DET) | Stephen Gostkowski |
| 4 | 19 | Buffalo Bills (from CIN) | Zach Strief |
| 4 | 20 | Green Bay Packers (from ATL) | Jack Coan |
| Round | Pick | Team | Selection |
|---|---|---|---|
| 5 | 1 | Detroit Lions (from IND) | Brandon McKinney |
| 5 | 2 | Tampa Bay Buccanneers (from GB) | Eric Smith |
| 5 | 3 | Chicago Bears | Fred Jackson |
| 5 | 4 | Buffalo Bills | Trevor Canfield |
| 5 | 5 | Seattle Seahawks (CLE) | Jason Avant |
| 5 | 6 | New York Jets | Kurt Quarterman |
| 5 | 7 | New York Giants | Abram Elam |
| 5 | 8 | Washington [Redacted]s (CHC) | Tarvaris Jackson |
| 5 | 9 | Minnesota Vikings | Nick Novak |
| 5 | 10 | Kansas City Chiefs | Connor Hughes |
| 5 | 11 | Miami Dolphins | Nevin McCaskill |
| 5 | 12 | Baltimore Ravens | Jonathan Scott |
| 5 | 13 | London Monarchs | Cedric Griffin |
| 5 | 14 | Providence Steam Rollers (SEA) | Rob Sims |
| 5 | 15 | Tampa Bay Buccanneers | Rashad Jeanty |
| 5 | 16 | San Francisco 49ers | Ryan Cook |
| 5 | 17 | Oakland Raiders | Marcus Vick |
| 5 | 18 | Detroit Lions | Ryan O'Callaghan |
| 5 | 19 | Buffalo Bills (from CIN) | Jo-Jo Townsell II |
| 5 | 20 | Atlanta Falcons | Rudy Niswanger |
| Round | Pick | Team | Selection |
|---|---|---|---|
| 6 | 1 | Indianapolis Colts | Jason Spitz |
| 6 | 2 | Green Bay Packers | Cliff Battles |
| 6 | 3 | Chicago Bears | J.P. Foschi |
| 6 | 4 | Buffalo Bills | Johnathan Joseph |
| 6 | 5 | Seattle Seahawks (CLE) | Michael Robinson |
| 6 | 6 | New York Jets | Darryl Tapp |
| 6 | 7 | Washington [Redacted]s (CHC) (from NYG) | Steve Weatherford |
| 6 | 8 | Washington [Redacted]s (CHC) | Steve Gregory |
| 6 | 9 | Minnesota Vikings | Diamond Ferri |
| 6 | 10 | Kansas City Chiefs | Jerious Norwood |
| 6 | 11 | Miami Dolphins | Markus Curry |
| 6 | 12 | Baltimore Ravens | Clint Ingram |
| 6 | 13 | London Monarchs | Dennis Roland |
| 6 | 14 | Providence Steam Rollers (SEA) | Anthony Smith |
| 6 | 15 | Tampa Bay Buccanneers | Jonathan Lewis |
| 6 | 16 | San Francisco 49ers | Ronnie Prude |
| 6 | 17 | Oakland Raiders | Bobby Carpenter |
| 6 | 18 | Detroit Lions | Jon Ryan |
| 6 | 19 | Cincinnati Bengals | Pat Watkins |
| 6 | 20 | Atlanta Falcons | Bernard Pollard |
| Round | Pick | Team | Selection |
|---|---|---|---|
| 7 | 1 | Indianapolis Colts | Derrick Martin |
| 7 | 2 | Green Bay Packers | Brian Calhoun |
| 7 | 3 | Chicago Bears | Kelly Jennings |
| 7 | 4 | Buffalo Bills | LenDale White |
| 7 | 5 | Seattle Seahawks (CLE) | Stephen Tulloch |
| 7 | 6 | New York Jets | DeDe Dorsey |
| 7 | 7 | Washington [Redacted]s (CHC) (from NYG) | Jeremy Cain |
| 7 | 8 | Washington [Redacted]s (CHC) | Michael Bragg |
| 7 | 9 | Minnesota Vikings | Norm Katnik |
| 7 | 10 | Kansas City Chiefs | Tyjuan Hagler |
| 7 | 11 | Green Bay Packers (from MIA) | Jarrett Bush |
| 7 | 12 | Baltimore Ravens | Dave Pearson |
| 7 | 13 | London Monarchs | Jamaica Rector |
| 7 | 14 | Providence Steam Rollers (SEA) | Daniel Bullocks |
| 7 | 15 | Tampa Bay Buccanneers | Darcy Johnson |
| 7 | 16 | San Francisco 49ers | Hank Baskett |
| 7 | 17 | Oakland Raiders | Anthony Fasano |
| 7 | 18 | Detroit Lions | Keith Ellison |
| 7 | 19 | Cincinnati Bengals | Corey Mays |
| 7 | 20 | Chicago Bears (from ATL) | Reed Doughty |